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Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function

Abstract:
We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged ion channel blockers in neurophysiology. © 2012 Landes Bioscience.

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Publisher copy:
10.4161/cib.19400

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Rodríguez-Moreno, A More by this author
Paulsen, O More by this author
Anderson, HL More by this author
Journal:
Communicative and Integrative Biology
Volume:
5
Issue:
3
Pages:
240-242
Publication date:
2012-05-05
DOI:
EISSN:
1942-0889
ISSN:
1942-0889
URN:
uuid:c0253382-65bd-4def-af08-6c710afc4843
Source identifiers:
350036
Local pid:
pubs:350036
Language:
English
Keywords:

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