The role of DNA exonucleases in protecting genome stability and their impact on ageing.
Exonucleases are key enzymes involved in many aspects of cellular metabolism and maintenance and are essential to genome stability, acting to cleave DNA from free ends. Exonucleases can act as proofreaders during DNA polymerisation in DNA replication, to remove unusual DNA structures that arise from problems with DNA replication fork progression, and they can be directly involved in repairing damaged DNA. Several exonucleases have been recently discovered, with potentially critical roles in g...Expand abstract
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- American Aging Association
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- © American Aging Association 2011. Published by Springer Verlag on behalf of the American Aging Association. This is the accepted manuscript version of the article. The final version is available online from Springer Verlag at: [10.1007/s11357-011-9306-5].
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