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The role of DNA exonucleases in protecting genome stability and their impact on ageing.

Abstract:

Exonucleases are key enzymes involved in many aspects of cellular metabolism and maintenance and are essential to genome stability, acting to cleave DNA from free ends. Exonucleases can act as proofreaders during DNA polymerisation in DNA replication, to remove unusual DNA structures that arise from problems with DNA replication fork progression, and they can be directly involved in repairing damaged DNA. Several exonucleases have been recently discovered, with potentially critical roles in g...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1007/s11357-011-9306-5

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Publisher:
Springer Verlag Publisher's website
Journal:
AGE Journal website
Volume:
34
Issue:
6
Pages:
1317-1340
Publication date:
2011-09-23
DOI:
EISSN:
1574-4647
ISSN:
0161-9152
URN:
uuid:c00dfa84-145b-467e-af6d-5804446ff201
Source identifiers:
180566
Local pid:
pubs:180566

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