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Facilitatory and inhibitory pain mechanisms are altered in patients with carpal tunnel syndrome

Abstract:

Preliminary evidence from studies using quantitative sensory testing suggests the presence of central mechanisms in patients with carpal tunnel syndrome (CTS) as apparent by widespread hyperalgesia. Hallmarks of central mechanisms after nerve injuries include nociceptive facilitation and reduced endogenous pain inhibition. Methods to study nociceptive facilitation in CTS so far have been limited to quantitative sensory testing and the integrity of endogenous inhibition remains unexamined. The...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0183252

Authors


Vicenzino, B More by this author
More by this author
Department:
Oxford, MSD, Clinical Neurosciences
Coppieters, MW More by this author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
8
Pages:
Article: e0183252
Publication date:
2017-08-30
DOI:
ISSN:
1932-6203
Pubs id:
pubs:726055
URN:
uri:bfff7d6a-39e5-4d21-b2ca-bcc9118ed09d
UUID:
uuid:bfff7d6a-39e5-4d21-b2ca-bcc9118ed09d
Local pid:
pubs:726055
Paper number:
8
Language:
English

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