Journal article

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

Abstract:: 2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. Using a representative 2OG oxygenase panel, we compare the inhibitory activities of 5-carboxy-8-hydroxyquinoline (IOX1) and 4-carboxy-8-hydroxyquinoline (4C8HQ) with that of two other commonly used 2OG oxygenase inhibitors, N-oxalylglycine (NOG) and 2,4-pyridinedicarboxylic acid (2,4-PDCA). The results reveal that IOX1 has a broad spectrum of activity, as demonstrated by the inhibition of transcription fa...
Expand abstract
Collapse abstract

Publication status:: Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Hopkinson, R., Tumber, A., Yapp, C., Chowdhury, R., Aik, W., Che, K., Li, X., Kristensen, J., King, O., Chan, M., Yeoh, K., Choi, H., Walport, L., Thinnes, C., Bush, J., Lejeune, C., Rydzik, A., Rose, N., Bagg, E., … Brennan, P. (2013). 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation. CHEMICAL SCIENCE, 4(8), 3110–3117.

MLA Style

Hopkinson, R., et al. “5-Carboxy-8-Hydroxyquinoline Is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor Which Causes Iron Translocation.” CHEMICAL SCIENCE, vol. 4, no. 8, 2013, pp. 3110–17.

Chicago Style

Hopkinson, R, A Tumber, C Yapp, R Chowdhury, W Aik, K Che, X Li, et al. 2013. “5-Carboxy-8-Hydroxyquinoline Is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor Which Causes Iron Translocation.” CHEMICAL SCIENCE 4 (8): 3110–17.
Tweet
Print

Access Document

Publisher copy:: 10.1039/c3sc51122g

Authors

+ Hopkinson, R More by this author

Role:

Author

+ Tumber, A More by this author

Role:

Author

+ Yapp, C More by this author

Role:

Author

+ Chowdhury, R More by this author

Role:

Author

+ Aik, W More by this author

Role:

Author

More authors...

Bibliographic Details

Journal:: CHEMICAL SCIENCE More from this journal
Volume:: 4
Issue:: 8
Pages:: 3110-3117
Publication date:: 2013-01-01
DOI:: 10.1039/c3sc51122g
EISSN:: 2041-6539
ISSN:: 2041-6520

Item Description

Language:: English
Pubs id:: pubs:415376
UUID:: uuid:bff94fed-dcda-46cf-a181-68857c229d02
Local pid:: pubs:415376
Source identifiers:: 415376
Deposit date:: 2013-11-17

Terms of use

Copyright date:: 2013

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Metrics

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP