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Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study

Abstract:

Background: Cardiovascular disease is a major cause of excess mortality in people with schizophrenia. Several factors are responsible, including lifestyle and metabolic effects of antipsychotics. However, variations in cardiac structure and function are seen in people with schizophrenia in the absence of cardiovascular disease risk factors and after accounting for lifestyle and medication. Therefore, we aimed to explore whether shared genetic causes contribute to thes...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1016/S2215-0366(22)00403-5

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Publisher:
Elsevier
Journal:
Lancet Psychiatry More from this journal
Volume:
10
Issue:
2
Pages:
98-107
Publication date:
2023-01-08
Acceptance date:
2022-11-18
DOI:
EISSN:
2215-0374
ISSN:
2215-0366
Language:
English
Keywords:
Pubs id:
1324755
Local pid:
pubs:1324755
Deposit date:
2023-02-02

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