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HmCRIP, a cysteine-rich intestinal protein, is expressed by an identified regenerating nerve cell

Abstract:

A Hirudo medicinalis cDNA isolated from regenerating CNS tissue at 24 h post-axotomy was identified as a leech homologue of the mammalian cysteine-rich intestinal proteins (CRIPs) and named HmCRIP. HmCRIP is up-regulated within 6 h of axotomy, peaking at 24 h. This is the first demonstration of a CRIP homologue in regenerating CNS and in a serotonergic neurone. In rodents CRIP is an important factor in the regulation of the inflammatory immune response through control of Th1/Th2 d...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S0014-5793(02)03741-9

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Institution:
University of Oxford
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Wadham College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
Role:
Author
Medical Research Council More from this funder
Human Frontier Science Programme More from this funder
Publisher:
Elsevier B.V. Publisher's website
Journal:
FEBS Letters Journal website
Volume:
533
Issue:
2
Pages:
124-128
Publication date:
2003-01-05
DOI:
EISSN:
0203-7419
ISSN:
0014-5793
URN:
uuid:bfdf3b08-4913-4d05-9ca9-121c87e72716
Local pid:
ora:8506

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