Journal article icon

Journal article

Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.

Abstract:

We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterize their association with intermediate phenotypes, and to investigate their role in type 2 diabetes (T2D) risk among normal-weight, overweight, and obese individuals. We investigated the association of genetic scores with euglycemic-hyperinsulinemic clamp- and oral glucose tolerance test-based measures of insulin resistance and secretion and a range of metabolic measures in up to 18,565 ind...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.2337/db14-0319

Authors


Expand authors...
Journal:
Diabetes
Volume:
63
Issue:
12
Pages:
4378-4387
Publication date:
2014-12-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:bfdb2fe9-c352-4da4-8a15-3a6816646577
Source identifiers:
471074
Local pid:
pubs:471074

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP