Journal article

Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.

Abstract:: Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (age stratification and metaregression) to conduct a genome-wide search of common variants with age-dependent effects on systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse (PP) pressure...
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Publication status:: Published

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APA Style

Simino, J., Shi, G., Bis, J., Chasman, D., Ehret, G., Gu, X., Guo, X., Hwang, S., Sijbrands, E., Smith, A., Verwoert, G., Bragg-Gresham, J., Cadby, G., Chen, P., Cheng, C., Corre, T., de Boer, R., Goel, A., Johnson, T., … Sim, X. (2014). Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. American Journal of Human Genetics, 95(1), 24–38.

MLA Style

Simino, J., et al. “Gene-Age Interactions in Blood Pressure Regulation: a Large-Scale Investigation with the CHARGE, Global BPgen, and ICBP Consortia.” American Journal of Human Genetics, vol. 95, no. 1, 2014, pp. 24–38.

Chicago Style

Simino, J, G Shi, J Bis, D Chasman, G Ehret, X Gu, X Guo, et al. 2014. “Gene-Age Interactions in Blood Pressure Regulation: a Large-Scale Investigation with the CHARGE, Global BPgen, and ICBP Consortia.” American Journal of Human Genetics 95 (1): 24–38.
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Publisher copy:: 10.1016/j.ajhg.2014.05.010

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+ Simino, J More by this author

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+ Shi, G More by this author

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+ Bis, J More by this author

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+ Chasman, D More by this author

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+ Ehret, G More by this author

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Bibliographic Details

Journal:: American journal of human genetics More from this journal
Volume:: 95
Issue:: 1
Pages:: 24-38
Publication date:: 2014-07-01
DOI:: 10.1016/j.ajhg.2014.05.010
EISSN:: 1537-6605
ISSN:: 0002-9297

Item Description

Language:: English
Keywords:: Adult

Age Factors

Blood Pressure

Young Adult

Cohort Studies

Aged

Adolescent

Middle Aged

Humans

LifeLines Cohort Study
Pubs id:: pubs:470992
UUID:: uuid:bfd7f46e-be65-4b23-a723-bc6caa2d1be8
Local pid:: pubs:470992
Source identifiers:: 470992
Deposit date:: 2014-07-15

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Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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