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The different approaches to the genetic analysis of autoimmune thyroid disease.

Abstract:

Graves' disease and Hashimoto's thyroiditis are organ-specific autoimmune disorders of multifactorial aetiology with a polygenic mode of inheritance. Familial clustering and twin studies provide evidence for a genetic predisposition. Three main approaches have been used in the search for susceptibility loci: population-based case-control studies, classical linkage analysis, and intrafamilial linkage disequilibrium. Case-control studies are a sensitive method of gene detection and the collecti...

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Publisher copy:
10.1677/joe.0.1630007

Authors


Allahabadia, A More by this author
Journal:
The Journal of endocrinology
Volume:
163
Issue:
1
Pages:
7-13
Publication date:
1999-10-05
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
URN:
uuid:bfcf24b1-f193-4a1c-bbc3-d937a0f71a55
Source identifiers:
176217
Local pid:
pubs:176217

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