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Structural basis for ASPP2 recognition by the tumor suppressor p73

Abstract:

Tumor suppressors p53, p63 and p73 comprise a family of stress-responsive transcription factors with distinct functions in development and tumor suppression. Most human cancers lose p53 function, yet all three proteins are capable of inducing apoptosis or cellular senescence. Mechanisms are therefore under investigation to activate p73-dependent apoptosis in p53-deficient cancer cells. Significantly, the DNA-binding domain (DBD) of p73 escapes viral oncoproteins and displays an enhanced therm...

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Publisher copy:
10.1016/j.jmb.2012.08.005

Authors


Canning, P More by this author
Von Delft, F More by this author
Bullock, AN More by this author
Journal:
Journal of Molecular Biology
Volume:
423
Issue:
4
Pages:
515-527
Publication date:
2012-11-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:bfcc9760-8dc4-4c15-9a5f-64161ec0d722
Source identifiers:
356625
Local pid:
pubs:356625
Language:
English
Keywords:

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