Journal article

Disruption of macrodomain protein SCO6735 increases antibiotic production in Streptomyces coelicolor

Abstract:: ADP-ribosylation is a post-translational modification that can alter the physical and chemical properties of target proteins and controls many important cellular processes. Macrodomains are evolutionarily conserved structural domains that bind ADP-ribose derivatives and are found in proteins with diverse cellular functions. Some proteins from the macrodomain family can hydrolyze ADP-ribosylated substrates and therefore reverse this post-translational modification. Bacteria and Streptomyces, i...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Lalić, J., Posavec Marjanović, M., Palazzo, L., Perina, D., Sabljić, I., Žaja, R., Colby, T., Pleše, B., Halasz, M., Jankevicius, G., Bucca, G., Ahel, M., Matić, I., Ćetković, H., Luić, M., Mikoč, A., & Ahel, I. (2016). Disruption of macrodomain protein SCO6735 increases antibiotic production in Streptomyces coelicolor. Journal of Biological Chemistry, 291(44), 23175–23187.

MLA Style

Lalić, J., et al. “Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production in Streptomyces Coelicolor.” Journal of Biological Chemistry, vol. 291, no. 44, American Society for Biochemistry and Molecular Biology, 2016, pp. 23175–87.

Chicago Style

Lalić, J, M Posavec Marjanović, L Palazzo, D Perina, I Sabljić, R Žaja, T Colby, et al. 2016. “Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production in Streptomyces Coelicolor.” Journal of Biological Chemistry 291 (44): 23175–87.
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Files:: J. Biol. Chem.-2016-Lali--23175-87.pdf

(Preview, pdf, 1.9MB, Terms of use)

Publisher copy:: 10.1074/jbc.M116.721894

Authors

+ Lalić, J More by this author

Role:

Author

+ Posavec Marjanović, M More by this author

Role:

Author

+ Palazzo, L More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Pathology Dunn School

Role:

Author

+ Perina, D More by this author

Role:

Author

+ Sabljić, I More by this author

Role:

Author

More authors...

Funding

+ Wellcome Trust More from this funder

Grant:

101794

+ Cancer Research UK More from this funder

Grant:

C35050/A22284

+ European Union More from this funder

Grant:

European Community's Seventh Framework Programme (FP7/2007-2013) under BioStruct-X (grant agreement N°283570

+ European Research Council More from this funder

Grant:

281739

+ Unity Through Knowledge Fund More from this funder

Grant:

UKF 1B 2/13

Bibliographic Details

Publisher:: American Society for Biochemistry and Molecular Biology
Journal:: Journal of Biological Chemistry More from this journal
Volume:: 291
Issue:: 44
Pages:: 23175-23187
Publication date:: 2016-09-15
DOI:: 10.1074/jbc.M116.721894
EISSN:: 1083-351X
ISSN:: 0021-9258

Item Description

Language:: English
Keywords:: post-translational modification (PTM)

Streptomyces

nicotinamide adenine dinucleotide (NAD)

microbiology

PARP

enzyme mechanism

ADP-ribose

DNA damage

ADP-ribosylation

antibiotics
Pubs id:: pubs:645879
UUID:: uuid:bfc3a7f8-4e22-46bf-90fa-e6e2b042e42c
Local pid:: pubs:645879
Deposit date:: 2016-09-22

Terms of use

Copyright holder:: The American Society for Biochemistry and Molecular Biology
Copyright date:: 2016
Notes:: Copyright © 2016 The American Society for Biochemistry and Molecular Biology. Final version free via Creative Commons CC-BY license.

Licence:: CC Attribution (CC BY)

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