Journal article
Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia.
- Abstract:
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Background
Improved diagnostics for typhoid are needed; a typhoid controlled human infection model may accelerate their development and translation. Here, we evaluated a blood culture-PCR assay for detecting infection after controlled human infection with S. Typhi and compared test performance with optimally performed blood cultures.
Methodology/Principal Findings
Culture-PCR amplification of blood samples was performed alongside daily blood culture in 41 particip...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(pdf, 1.1MB)
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- Publisher copy:
- 10.1016/j.jinf.2017.01.006
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Authors
Funding
+ National Institute for Health Research
More from this funder
Funding agency for:
Pollard, A
Grant:
100087/Z/12/Z
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Infection Journal website
- Publication date:
- 2017-01-01
- Acceptance date:
- 2017-01-14
- DOI:
- ISSN:
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1532-2742
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:673519
- UUID:
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uuid:bfb92673-fb92-439d-911f-ccdb798ada3e
- Local pid:
- pubs:673519
- Deposit date:
- 2017-02-07
Terms of use
- Copyright holder:
- Pollard et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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