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Journal article

Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia.

Abstract:

Background

Improved diagnostics for typhoid are needed; a typhoid controlled human infection model may accelerate their development and translation. Here, we evaluated a blood culture-PCR assay for detecting infection after controlled human infection with S. Typhi and compared test performance with optimally performed blood cultures.

Methodology/Principal Findings

Culture-PCR amplification of blood samples was performed alongside daily blood culture in 41 particip...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jinf.2017.01.006

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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More from this funder
Funding agency for:
Pollard, A
Grant:
100087/Z/12/Z
More from this funder
Funding agency for:
Pollard, A
Grant:
100087/Z/12/Z
More from this funder
Funding agency for:
Pollard, A
Grant:
100087/Z/12/Z
More from this funder
Funding agency for:
Pollard, A
Grant:
100087/Z/12/Z
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Infection Journal website
Publication date:
2017-01-01
Acceptance date:
2017-01-14
DOI:
ISSN:
1532-2742
Language:
English
Keywords:
Pubs id:
pubs:673519
UUID:
uuid:bfb92673-fb92-439d-911f-ccdb798ada3e
Local pid:
pubs:673519
Deposit date:
2017-02-07

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