microMRI-HREM pipeline for high-throughput, high-resolution phenotyping of murine embryos.

Journal article

Rapid and precise phenotyping analysis of large numbers of wild-type and mutant mouse embryos is essential for characterizing the genetic and epigenetic factors regulating embryogenesis. We present a novel methodology that permits precise high-throughput screening of the phenotype of embryos with both targeted and randomly generated mutations. To demonstrate the potential of this methodology we show embryo phenotyping results produced in a large-scale ENU-mutagenesis study. In essence this re...

Expand abstract

Authors: Pieles, G; Geyer, S; Szumska, D; Schneider, J; Neubauer, S

• Publication status: Published
• Journal: Journal of anatomy
• Volume: 211
• Issue: 1
• Pages: 132-137
• Publication date: 2007-07-01
• DOI: 10.1111/j.1469-7580.2007.00746.x
• EISSN: 1469-7580
• ISSN: 0021-8782
• Language: English
• Keywords: Staining and Labeling; Phenotype; Animals; Embryo, Mammalian; Pattern Recognition, Automated; Magnetic Resonance Imaging; Mice, Mutant Strains; Mice; Imaging, Three-Dimensional