Proteomic analysis of Plasmodium in the mosquito: progress and pitfalls.

Journal article

Here we discuss proteomic analyses of whole cell preparations of the mosquito stages of malaria parasite development (i.e. gametocytes, microgamete, ookinete, oocyst and sporozoite) of Plasmodium berghei. We also include critiques of the proteomes of two cell fractions from the purified ookinete, namely the micronemes and cell surface. Whereas we summarise key biological interpretations of the data, we also try to identify key methodological constraints we have met, only some of which we were...

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Authors: Wass, M; Stanway, R; Blagborough, A; Lal, K; Prieto, J

• Journal: Parasitology
• Volume: 139
• Issue: 9
• Pages: 1131-1145
• Publication date: 2012-08-01
• DOI: 10.1017/s0031182012000133
• EISSN: 1469-8161
• ISSN: 0031-1820
• Language: English
• Keywords: Proteomics; Protozoan Proteins; Malaria; Animals; Insect Vectors; Female; Male; Plasmodium berghei; Life Cycle Stages; Culicidae