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The molecular structure of a 4'-epiadriamycin complex with d(TGATCA) at 1.7A resolution: comparison with the structure of 4'-epiadriamycin d(TGTACA) and d(CGATCG) complexes.

Abstract:

The structure of the complex between d(TGATCA) and the anthracycline 4'-epiadriamycin has been determined by crystallographic methods. The crystals are tetragonal, space group P4(1)2(1)2 with unit cell dimensions of a = 28.01, c = 52.95A. The asymmetric unit consists of one strand of hexanucleotide, one molecule of 4'-epiadriamycin and 34 waters. The R-factor is 20.2% for 1694 reflections with F greater than or equal to 2 sigma F to 1.7A. Two asymmetric units associate to generate a duplex co...

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Publication status:
Published

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Publisher copy:
10.1093/nar/20.14.3561

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Nucleic acids research
Volume:
20
Issue:
14
Pages:
3561-3566
Publication date:
1992-07-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:bf8d649b-d01b-45a5-8a72-2fde054d1a70
Source identifiers:
400400
Local pid:
pubs:400400

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