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Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease.

Abstract:

Post-transcriptional control of mitochondrial gene expression, including the processing and generation of mature transcripts as well as their degradation, is a key regulatory step in gene expression in human mitochondria. Consequently, identification of the proteins responsible for RNA processing and degradation in this organelle is of great importance. The metallo-β-lactamase (MBL) is a candidate protein family that includes ribo- and deoxyribonucleases. In this study, we discovered a functi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkw050

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Role:
Author
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Israel Science Foundation More from this funder
Structural Genomics Consortium More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
44
Issue:
4
Pages:
1813-1832
Publication date:
2016-01-29
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:bf8b4deb-58ac-4e6e-b559-1c6bd435ef97
Source identifiers:
601497
Local pid:
pubs:601497
Language:
English

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