Identification of an intestinal heme transporter.

Journal article

Dietary heme iron is an important nutritional source of iron in carnivores and omnivores that is more readily absorbed than non-heme iron derived from vegetables and grain. Most heme is absorbed in the proximal intestine, with absorptive capacity decreasing distally. We utilized a subtractive hybridization approach to isolate a heme transporter from duodenum by taking advantage of the intestinal gradient for heme absorption. Here we show a membrane protein named HCP 1 (heme carrier protein 1)...

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Authors: Shayeghi, M; Latunde-Dada, G; Oakhill, J; Laftah, A; Takeuchi, K

• Publication status: Published
• Journal: Cell
• Volume: 122
• Issue: 5
• Pages: 789-801
• Publication date: 2005-09-01
• DOI: 10.1016/j.cell.2005.06.025
• EISSN: 1097-4172
• ISSN: 0092-8674
• Language: English
• Keywords: Intestinal Absorption; CHO Cells; RNA, Messenger; Xenopus; Iron; Hela Cells; Cloning, Molecular; Oocytes; Membrane Transport Proteins; Heme; Humans; Sequence Alignment; Transferrin; Proton-Coupled Folate Transporter; Mice; Zebrafish; Epithelial Cells; Cricetinae; Animals; Duodenum; Anoxia; Rabbits; Bacterial Proteins; Rats; Carrier Proteins; Amino Acid Sequence; Molecular Sequence Data