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First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial.

Abstract:

BACKGROUND: Children with HIV will be on antiretroviral therapy (ART) longer than adults, and therefore the durability of first-line ART and timing of switch to second-line are key questions. We assess the long-term outcome of protease inhibitor and non-nucleoside reverse transcriptase inhibitor (NNRTI) first-line ART and viral load switch criteria in children. METHODS: In a randomised open-label factorial trial, we compared effectiveness of two nucleoside reverse transcriptase inhibitors (NR...

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Publication status:
Published

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Journal:
The Lancet. Infectious diseases
Volume:
11
Issue:
4
Pages:
273-283
Publication date:
2011-04-05
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:bf7a9cdb-6dfe-42d2-8dce-87491fec385a
Source identifiers:
422612
Local pid:
pubs:422612

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