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Sialic acid mediated transcriptional modulation of a highly conserved sialometabolism gene cluster in Haemophilus influenzae and its effect on virulence

Abstract:

Background. Sialic acid has been shown to be a major virulence determinant in the pathogenesis of otitis media caused by the bacterium Haemophilus influenzae. This study aimed to characterise the expression of genes required for the metabolism of sialic acid and to investigate the role of these genes in virulence. Results. Using qRT-PCR, we observed decreased transcriptional activity of genes within a cluster that are required for uptake and catabolism of 5-acetyl neuraminic acid (Neu5Ac), wh...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2180-10-48

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Author
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Funding agency for:
Jenkins, GA
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Funding agency for:
Kumar, GA
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC Microbiology Journal website
Volume:
10
Issue:
1
Pages:
Article: 48
Publication date:
2010-02-16
DOI:
EISSN:
1471-2180
ISSN:
1471-2180
URN:
uuid:bf766a87-7691-468e-8721-3185eb45580d
Source identifiers:
115637
Local pid:
pubs:115637

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