Journal article
Sialic acid mediated transcriptional modulation of a highly conserved sialometabolism gene cluster in Haemophilus influenzae and its effect on virulence
- Abstract:
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Background. Sialic acid has been shown to be a major virulence determinant in the pathogenesis of otitis media caused by the bacterium Haemophilus influenzae. This study aimed to characterise the expression of genes required for the metabolism of sialic acid and to investigate the role of these genes in virulence. Results. Using qRT-PCR, we observed decreased transcriptional activity of genes within a cluster that are required for uptake and catabolism of 5-acetyl neuraminic acid (Neu5Ac), wh...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1186/1471-2180-10-48
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Bibliographic Details
- Publisher:
- BioMed Central
- Journal:
- BMC Microbiology More from this journal
- Volume:
- 10
- Issue:
- 1
- Article number:
- 48
- Publication date:
- 2010-02-16
- DOI:
- EISSN:
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1471-2180
- ISSN:
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1471-2180
Item Description
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:bf766a87-7691-468e-8721-3185eb45580d
- Local pid:
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pubs:115637
- Source identifiers:
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115637
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- Jenkins et al
- Copyright date:
- 2010
- Notes:
- © 2010 Jenkins et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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