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TGF-β-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2.

Abstract:

Foxp3 plays an important role in the development and the function of regulatory T cells (Treg). Both the induction and maintenance of Foxp3 gene expression are controlled by several regulatory regions including two enhancers in the conserved noncoding sequences (CNS). The functions of Enhancer 1 in CNS1 are well established, whereas those of Enhancer 2 in CNS2 remain unclear. Although CNS2 contains enhancer activity, methylated CpG sequences in this region prevent Foxp3 gene expression in Fox...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1301892

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
192
Issue:
1
Pages:
475-483
Publication date:
2014-01-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:bf593ce2-8a8f-49f9-b13f-b988a2d9fe0b
Source identifiers:
447479
Local pid:
pubs:447479

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