TGF-β-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2.

Journal article

Foxp3 plays an important role in the development and the function of regulatory T cells (Treg). Both the induction and maintenance of Foxp3 gene expression are controlled by several regulatory regions including two enhancers in the conserved noncoding sequences (CNS). The functions of Enhancer 1 in CNS1 are well established, whereas those of Enhancer 2 in CNS2 remain unclear. Although CNS2 contains enhancer activity, methylated CpG sequences in this region prevent Foxp3 gene expression in Fox...

Expand abstract

Authors: Ogawa, C; Tone, Y; Tsuda, M; Peter, C; Waldmann, H

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 192
• Issue: 1
• Pages: 475-483
• Publication date: 2014-01-01
• DOI: 10.4049/jimmunol.1301892
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Transforming Growth Factor beta; T-Lymphocytes, Regulatory; Cyclic AMP Response Element-Binding Protein; Enhancer Elements, Genetic; Animals; Binding Sites; Mice; Transcription Factor AP-1; Base Sequence; Forkhead Transcription Factors; STAT5 Transcription Factor; Histones; Molecular Sequence Data; Regulatory Sequences, Nucleic Acid; Acetylation; Gene Expression Regulation