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Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats

Abstract:

Dimethyloxalylglycine (DMOG) is an inhibitor of prolyl-4-hydroxylase domain (PHD) enzymes that regulate the stability of hypoxia-inducible factor (HIF). We investigated the effect of DMOG on the outcome after permanent and transient middle cerebral artery occlusion (p/tMCAO) in the rat. Before and after pMCAO, rats were treated with 40 mg/kg, 200 mg/kg DMOG, or vehicle, and with 40 mg/kg or vehicle after tMCAO. Serial magnetic resonance imaging (MRI) was performed to assess infarct evolution ...

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Publisher copy:
10.1038/jcbfm.2010.60

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
Journal:
Journal of Cerebral Blood Flow and Metabolism
Volume:
31
Issue:
1
Pages:
132-143
Publication date:
2011-01-01
DOI:
ISSN:
0271-678X
Source identifiers:
112652
Language:
English
Keywords:
Pubs id:
pubs:112652
UUID:
uuid:bf486781-d0ff-4403-ae85-8e154ba26286
Local pid:
pubs:112652
Deposit date:
2012-12-19

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