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Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade

Abstract:

Emerging evidence suggests a role for radiation in eliciting anti‐tumour immunity. We aimed to investigate the role of macrophages in modulating the immune response to radiation. Irradiation to murine tumours generated from colorectal (MC38) and pancreatic (KPC) cell lines induced colony‐stimulating factor 1 (CSF‐1). Coincident with the elevation in CSF‐1, macrophages increased in tumours, peaking 5 days following irradiation. These tumour‐associated macrophages (TAMs) were skewed towards an ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.15252/emmm.201809342

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Tiersma, J More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
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Funding agency for:
Jones, KI
Publisher:
EMBO Press Publisher's website
Journal:
EMBO Molecular Medicine Journal website
Volume:
10
Issue:
12
Pages:
Article: e9342
Publication date:
2018-11-15
Acceptance date:
2018-10-19
DOI:
Pubs id:
pubs:942698
URN:
uri:bf47f6c0-c2b4-422f-8a51-c34abf197d17
UUID:
uuid:bf47f6c0-c2b4-422f-8a51-c34abf197d17
Local pid:
pubs:942698

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