Journal article
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
- Abstract:
-
The disintegrin and metalloprotease ADAM12 has important functions in normal physiology as well as in diseases, such as cancer. Little is known about how ADAM12 confers its pro-tumorigenic effect; however, its proteolytic capacity is probably a key component. Thus selective inhibition of ADAM12 activity may be of great value therapeutically and as an investigative tool to elucidate its mechanisms of action. We have previously reported the inhibitory profile of TIMPs (tissue inhibitor of metal...
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- Publication status:
- Published
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- Publisher copy:
- 10.1042/bj20100649
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Authors
Bibliographic Details
- Journal:
- Biochemical journal
- Volume:
- 430
- Issue:
- 1
- Pages:
- 79-86
- Publication date:
- 2010-08-01
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- Source identifiers:
-
226806
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:226806
- UUID:
-
uuid:bf3e0eb6-bd3b-4d2b-b8ba-6dab6b98ad34
- Local pid:
- pubs:226806
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2010
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