- Abstract:
-
The disintegrin and metalloprotease ADAM12 has important functions in normal physiology as well as in diseases, such as cancer. Little is known about how ADAM12 confers its pro-tumorigenic effect; however, its proteolytic capacity is probably a key component. Thus selective inhibition of ADAM12 activity may be of great value therapeutically and as an investigative tool to elucidate its mechanisms of action. We have previously reported the inhibitory profile of TIMPs (tissue inhibitor of metal...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1042/bj20100649
-
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- Journal:
- The Biochemical journal
- Volume:
- 430
- Issue:
- 1
- Pages:
- 79-86
- Publication date:
- 2010-08-05
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- URN:
-
uuid:bf3e0eb6-bd3b-4d2b-b8ba-6dab6b98ad34
- Source identifiers:
-
226806
- Local pid:
- pubs:226806
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
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