NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.
Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease. We have tested here the relevance of additional homeostatic deviations that result from loss of activity of transcription factor NRF2, a crucial regulator of multiple stress responses whose activity declines with ageing. A transcriptomic analysis demonstrated that NRF2-KO mouse brains reproduc...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 1.1MB)
- Publisher copy:
- Copyright holder:
- Rojo et al
- Copyright date:
- © 2017 The Authors. Published by Elsevier B.V. Available under a Creative Commons CC-BY-NC-ND 4.0 license.
If you are the owner of this record, you can report an update to it here: Report update to this record