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NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.

Abstract:

Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease. We have tested here the relevance of additional homeostatic deviations that result from loss of activity of transcription factor NRF2, a crucial regulator of multiple stress responses whose activity declines with ageing. A transcriptomic analysis demonstrated that NRF2-KO mouse brains reproduc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.redox.2017.07.006

Authors


Pajares, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
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Publisher:
Elsevier Publisher's website
Journal:
Redox Biology Journal website
Volume:
13
Pages:
444-451
Publication date:
2017-07-05
Acceptance date:
2017-07-03
DOI:
EISSN:
2213-2317
ISSN:
2213-2317
Pubs id:
pubs:708879
URN:
uri:bf3c6b3b-4e4b-493b-8ecc-46685ebe20e8
UUID:
uuid:bf3c6b3b-4e4b-493b-8ecc-46685ebe20e8
Local pid:
pubs:708879

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