Molecular structure of human histocompatibility antigens: the HLA-C series.

Journal article

The HLA-CW2 antigen of the B lymphoblastoid cell line BRI 8 is structurally homologous to the HLA-A and B antigens as judged by various criteria. Each antigen comprised a glycosylated polypeptide of 43 000 molecular weight that is noncovalently associated with beta2-microglobulin (beta2m). Some small differences in molecular parameters were, however, revealed. Thus, the deoxycholate-solubilized HLA-CW2 antigen sedimented at the same rate as the HLA-A antigens but at a slightly faster rate tha...

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Authors: Snary, D; Barnstable, C; Bodmer, W; Crumpton, M

• Publication status: Published
• Journal: European journal of immunology
• Volume: 7
• Issue: 8
• Pages: 580-585
• Publication date: 1977-08-01
• DOI: 10.1002/eji.1830070816
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Molecular Weight; Molecular Conformation; Lymphocytes; HLA Antigens; Glycoproteins; Chemistry; Histocompatibility Antigens; Cell Membrane; Humans; beta 2-Microglobulin; Cell Line; Chemical Phenomena