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Journal article

HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.

Abstract:

A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using c...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jiu214

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Journal:
The Journal of infectious diseases
Volume:
210
Issue:
7
Pages:
1047-1051
Publication date:
2014-10-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:bf22a587-4c14-41ae-86f7-4fa9f210e690
Source identifiers:
465122
Local pid:
pubs:465122

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