Contributions of inwardly rectifying K+ currents to repolarization assessed using mathematical models of human ventricular myocytes.

Journal article

Repolarization of the action potential (AP) in cardiac muscle is a major determinant of refractoriness and excitability, and can also strongly modulate excitation-contraction coupling. In clinical cardiac electrophysiology, the Q-T interval, and hence action potential duration, is both an essential marker of normal function and an indicator of risk for arrhythmic events. It is now well known that the termination of the plateau phase of the AP and the repolarization waveform involve a complex ...

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Authors: Fink, M; Giles, W; Noble, D

• Publication status: Published
• Journal: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
• Volume: 364
• Issue: 1842
• Pages: 1207-1222
• Publication date: 2006-05-01
• DOI: 10.1098/rsta.2006.1765
• EISSN: 1471-2962
• ISSN: 1364-503X
• Language: English
• Keywords: Heart Ventricles; Ion Channel Gating; Cells, Cultured; Calcium Signaling; Computer Simulation; Potassium; Muscle Cells; Ventricular Function; Action Potentials; Models, Cardiovascular; Humans; Potassium Channels, Inwardly Rectifying; Membrane Potentials; Calcium