Journal article icon

Journal article

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases.

Abstract:

Short-chain dehydrogenases/reductases form a large, evolutionarily old family of NAD(P)(H)-dependent enzymes with over 60 genes found in the human genome. Despite low levels of sequence identity (often 10-30%), the three-dimensional structures display a highly similar alpha/beta folding pattern. We have analyzed the role of several conserved residues regarding folding, stability, steady-state kinetics, and coenzyme binding using bacterial 3beta/17beta-hydroxysteroid dehydrogenase and selected...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m202160200

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Expand authors...
Journal:
Journal of biological chemistry
Volume:
277
Issue:
28
Pages:
25677-25684
Publication date:
2002-07-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
108576

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP