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CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.

Abstract:

CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and splenic dendritic cells (sDC), is increased following stimulation via Toll-like receptor (TLR)3 and TLR9. Nuclear factor-kappaB activation, an important downstream consequence o...

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Authors


Petrova, S More by this author
Tchilian, EZ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
Immunology
Volume:
118
Issue:
2
Pages:
250-256
Publication date:
2006-06-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:befbe82c-e69b-44d5-8760-5750fe4b0ff2
Source identifiers:
33504
Local pid:
pubs:33504

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