- Abstract:
- An R638A mutation of the polymerase acidic protein (PA) subunit of the RNA polymerase of influenza A/WSN/33 virus results in severe attenuation of viral growth in cell culture by promoting the synthesis of defective interfering RNAs. We propose that R638A is an "elongation" mutant that destabilizes PA-RNA template interactions during elongation. A C453R mutation in PA can compensate for this defect, suggesting that amino acids C453 and R638 form part of the same domain.
- Publication status:
- Published
- Publisher copy:
- 10.1128/jvi.77.8.5017-5020.2003
-
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- Journal:
- Journal of virology
- Volume:
- 77
- Issue:
- 8
- Pages:
- 5017-5020
- Publication date:
- 2003-04-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:befb70b7-6120-4401-9f88-c90c117a01c7
- Source identifiers:
-
24505
- Local pid:
- pubs:24505
- Copyright date:
- 2003
Journal article
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs.
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