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Cytokine gene transcription of human colonic intraepithelial lymphocytes costimulated with epithelial cells bearing HLA-DR and its inhibition by 5-aminosalicylic acid.

Abstract:

The objectives of this study were to activate human colonic intraepithelial lymphocytes at the transcriptional level with HLA-DR+ human colonic epithelial cell line (HT29) in synergy with CD3 monoclonal antibody and to investigate the molecular mechanism for the therapeutic effects of 5-aminosalicylic acid. Lymphocytes were isolated by a mechanical method from resected colon of 22 cases and then cocultured on 10 ng/ml CD3mAb immobilized plates with HT29 which had been induced to express MHC c...

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Publication status:
Published

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Publisher copy:
10.1007/bf01541230

Authors


Radford-Smith, G More by this author
Dipaolo, MC More by this author
McGowan, I More by this author
Jewell, DP More by this author
Journal:
Journal of clinical immunology
Volume:
16
Issue:
4
Pages:
237-241
Publication date:
1996-07-05
DOI:
EISSN:
1573-2592
ISSN:
0271-9142
URN:
uuid:bef35e65-e2b2-4112-82ab-2cefdcea650f
Source identifiers:
135438
Local pid:
pubs:135438

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