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CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

Abstract:

The ligand for CD40 (CD40L) is expressed on the surface of activated CD4+ T cells and its role in T-B cell collaborations and thymus-dependent humoral immunity is well established. Recently, by generating CD40L-knockout mice, we have confirmed its previously described role in humoral immunity and defined another important function of this molecule in the in vivo clonal expansion of antigen-specific CD4+ T cells. Here, we investigated the potential in vivo role of CD40L in antiviral immunity b...

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Publication status:
Published

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Publisher copy:
10.1084/jem.183.5.2129

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Journal:
Journal of experimental medicine
Volume:
183
Issue:
5
Pages:
2129-2142
Publication date:
1996-05-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
35915

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