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Production and characterization of novel anti-prostate-specific antigen (PSA) monoclonal antibodies that do not detect internally cleaved Lys145-Lys146 inactive PSA.

Abstract:

BACKGROUND: The nature of free, uncomplexed prostate-specific antigen (PSA) in the circulation is still unknown. In this study, we developed novel anti-PSA antibodies using PSA produced by a metastasized cancer cell line, LNCaP, as an immunogen. METHODS: Hybridoma cell lines were screened with different methods that aimed at finding antibodies specific for the forms of free PSA produced by LNCaP cell line. Obtained antibodies were further studied for their characteristics related to previousl...

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Authors


Nurmikko, P More by this author
Väisänen, V More by this author
Piironen, T More by this author
Lindgren, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
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Journal:
Clinical chemistry
Volume:
46
Issue:
10
Pages:
1610-1618
Publication date:
2000-10-05
EISSN:
1530-8561
ISSN:
0009-9147
URN:
uuid:bedd92a7-1cfa-4163-b682-4aa587e81d08
Source identifiers:
366052
Local pid:
pubs:366052

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