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Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells.

Abstract:

Many anticancer drugs require interaction with DNA or chromatin components of tumor cells to achieve therapeutic activity. Quantification and exploration of drug targeting dynamics can be highly informative in the rational development of new therapies and in the drug discovery pipeline. The problems faced include the potential infrequency and transient nature of critical events, the influence of micropharmacokinetics on the drug-target equilibria, the dependence on preserving cell function to...

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Publication status:
Published

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Publisher copy:
10.1016/j.addr.2004.05.005

Authors


Errington, RJ More by this author
Ameer-Beg, SM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Patterson, LH More by this author
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Journal:
Advanced drug delivery reviews
Volume:
57
Issue:
1
Pages:
153-167
Publication date:
2005-01-05
DOI:
EISSN:
1872-8294
ISSN:
0169-409X
URN:
uuid:bedbd0b0-c0f2-4e43-9e7e-c4943c572070
Source identifiers:
131157
Local pid:
pubs:131157

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