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Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)

Abstract:

The mammalian ubiquitin ligase Hrd1 is the central component of a complex facilitating degradation of misfolded proteins during the ubiquitin-proteasome dependent process of ER-associated degradation (ERAD). Hrd1 associates with cofactors to execute ERAD, but their roles and how they assemble with Hrd1 are not well understood. Here we identify crucial cofactor interaction domains within Hrd1 and report a previously unrecognised evolutionarily conserved segment within the intrinsically disorde...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/jcs.206847

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Ludwig Institute for Cancer Research More from this funder
Publisher:
Company of Biologists Publisher's website
Journal:
Journal of Cell Science Journal website
Volume:
130
Pages:
3322-3335
Publication date:
2017-08-21
Acceptance date:
2017-08-16
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
Pmid:
28827405
Language:
English
Keywords:
Pubs id:
pubs:724220
UUID:
uuid:bed8e119-d4b4-47ff-b737-d571ca6f5240
Local pid:
pubs:724220
Source identifiers:
724220
Deposit date:
2017-09-26

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