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Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)

Abstract:

The mammalian ubiquitin ligase Hrd1 is the central component of a complex facilitating degradation of misfolded proteins during the ubiquitin-proteasome dependent process of ER-associated degradation (ERAD). Hrd1 associates with cofactors to execute ERAD, but their roles and how they assemble with Hrd1 are not well understood. Here we identify crucial cofactor interaction domains within Hrd1 and report a previously unrecognised evolutionarily conserved segment within the intrinsically disorde...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1242/jcs.206847

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Gutschmidt, A More by this author
Dreher, LS More by this author
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Ludwig Institute for Cancer Research More from this funder
Publisher:
Company of Biologists Publisher's website
Journal:
Journal of Cell Science Journal website
Volume:
130
Pages:
3322-3335
Publication date:
2017-08-21
Acceptance date:
2017-08-16
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
Pubs id:
pubs:724220
URN:
uri:bed8e119-d4b4-47ff-b737-d571ca6f5240
UUID:
uuid:bed8e119-d4b4-47ff-b737-d571ca6f5240
Local pid:
pubs:724220

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