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31P nuclear magnetic resonance study of steady-state adenosine 5'-triphosphate levels during graded hypoxia in the isolated perfused rat kidney.

Abstract:

1. A model of controlled hypoxia in the isolated perfused rat kidney has been used to compare the extent of reduction in the steady-state level of adenosine 5'-triphosphate (ATP) from that initially observed with alterations in renal function and with the development of tubular cell injury. 2. ATP depletion was observed in response to decreased total oxygen delivery even when delivery greatly exceeded consumption and the venous oxygen tension remained in excess of 150 mmHg. 3. Increases in th...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
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Journal:
Clinical science (London, England : 1979)
Volume:
74
Issue:
4
Pages:
437-448
Publication date:
1988-04-05
EISSN:
1470-8736
ISSN:
0143-5221
URN:
uuid:bebb737c-d15c-47b1-91f7-868bd9c7ff3c
Source identifiers:
27009
Local pid:
pubs:27009

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