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Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus

Abstract:

Lichen sclerosus is a common, acquired chronic inflammatory skin disease of unknown etiology, although circulating autoantibodies to the glycoprotein extracellular matrix protein 1 (ECM1) have been detected in most patients' sera. We have examined the nature of ECM1 epitopes in lichen sclerosus sera, developed an ELISA system for serologic diagnosis, and assessed clinicopathological correlation between ELISA titer and disease. Epitope-mapping studies revealed that lichen sclerosus sera most f...

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Publication status:
Published

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Publisher copy:
10.1172/GCI200420373

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Journal:
JOURNAL OF CLINICAL INVESTIGATION
Volume:
113
Issue:
11
Pages:
1550-1559
Publication date:
2004-06-05
DOI:
ISSN:
0021-9738
URN:
uuid:beba707b-54d8-4062-ade9-b39fb68c6a68
Source identifiers:
19550
Local pid:
pubs:19550
Language:
English

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