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Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.

Abstract:

BACKGROUND and AIMS: Immune responses in the intestine are controlled by regulatory T cells (Tregs), which prevent inflammation in response to commensal bacteria. A specific population of intestinal dendritic cells (DCs), marked by expression of CD103, generate Tregs more efficiently than other DC populations through mechanisms that involve retinoic acid and transforming growth factor (TGF)-β. However, it is not clear how CD103(+) DCs are specialized for this function. We investigated the abi...

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Publication status:
Published

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Authors


Païdassi, H More by this author
Acharya, M More by this author
Mukhopadhyay, S More by this author
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Journal:
Gastroenterology
Volume:
141
Issue:
5
Pages:
1813-1820
Publication date:
2011-11-05
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
URN:
uuid:beb9aa9d-4424-4f7f-bdff-3369e7d45153
Source identifiers:
206167
Local pid:
pubs:206167

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