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Plasmodium berghei: lactic acidosis and hypoglycaemia in a rodent model of severe malaria; effects of glucose, quinine, and dichloroacetate.

Abstract:

Fulminant malaria infections are characterised by hypoglycaemia and potentially lethal lactic acidosis. In young adult Wistar rats (n = 26) infected with Plasmodium berghei (ANKA strain), hyperparasitaemia (greater than 50%), anaemia (PCV 19.6 +/- 5.3%; mean +/- SD) hypoglycaemia (1.04 +/- 0.74 mmol/litre), hyperlactataemia (13.2 +/- 2.20 mmol/litre), hyperpyruvicaemia (0.51 +/- 0.12 mmol/litre) and metabolic acidosis (arterial pH 6.96 +/- 0.11) developed after approximately 14 days of infect...

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Publication status:
Published

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Authors


Holloway, PA More by this author
Krishna, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Journal:
Experimental parasitology
Volume:
72
Issue:
2
Pages:
123-133
Publication date:
1991-02-05
DOI:
EISSN:
1090-2449
ISSN:
0014-4894
URN:
uuid:beb4384d-1523-4f14-8075-bd5deb66363e
Source identifiers:
34485
Local pid:
pubs:34485

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