- Abstract:
-
Fulminant malaria infections are characterised by hypoglycaemia and potentially lethal lactic acidosis. In young adult Wistar rats (n = 26) infected with Plasmodium berghei (ANKA strain), hyperparasitaemia (greater than 50%), anaemia (PCV 19.6 +/- 5.3%; mean +/- SD) hypoglycaemia (1.04 +/- 0.74 mmol/litre), hyperlactataemia (13.2 +/- 2.20 mmol/litre), hyperpyruvicaemia (0.51 +/- 0.12 mmol/litre) and metabolic acidosis (arterial pH 6.96 +/- 0.11) developed after approximately 14 days of infect...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/0014-4894(91)90130-o
-
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- Journal:
- Experimental parasitology
- Volume:
- 72
- Issue:
- 2
- Pages:
- 123-133
- Publication date:
- 1991-02-05
- DOI:
- EISSN:
-
1090-2449
- ISSN:
-
0014-4894
- URN:
-
uuid:beb4384d-1523-4f14-8075-bd5deb66363e
- Source identifiers:
-
34485
- Local pid:
- pubs:34485
- Copyright date:
- 1991
Journal article
Plasmodium berghei: lactic acidosis and hypoglycaemia in a rodent model of severe malaria; effects of glucose, quinine, and dichloroacetate.
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