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Thesis

Organosilicon reagents in carbon-carbon bond forming reactions: towards the total synthesis of incednine

Abstract:

This thesis investigates a total synthesis of the incednine aglycon by utilising alkenylsilane reagents to assemble the pentaenyl and tetraenyl systems through cross-coupling reactions. The early chapters develop methodology to access both cyclic alkenylsiloxanes and functionalised (E)-alkenylsilanes by the controlled hydrogenation of alkynylsiloxanes and silylolefination of aldehydes, respectively, and culminate in the synthesis of a C6-C13 bis(alkenylsilane)incednine fragment (S...

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Institution:
University of Oxford
Research group:
Edward Anderson
Oxford college:
Merton College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry
Role:
Author

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Role:
Supervisor
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Funding agency for:
Diane S W Lim
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:beb3e9cb-087d-4c96-97f4-da611d08f9f9
Local pid:
ora:8967

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