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The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory.

Abstract:

Mutations in the amnesiac gene in Drosophila affect both memory retention and ethanol sensitivity. The predicted amnesiac gene product, AMN, is an apparent preproneuropeptide, and previous studies suggest that it stimulates cAMP synthesis. Here we show that, unlike other learning-related Drosophila proteins, AMN is not preferentially expressed in mushroom bodies. Instead, it is strongly expressed in two large neurons that project over all the lobes of the mushroom bodies, a finding that sugge...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Armstrong, JD More by this author
Kitamoto, T More by this author
Journal:
Cell
Volume:
103
Issue:
5
Pages:
805-813
Publication date:
2000-11-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:bea7e541-31a1-4cac-921a-111177e9a2d7
Source identifiers:
428110
Local pid:
pubs:428110

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