The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory.

Journal article

Mutations in the amnesiac gene in Drosophila affect both memory retention and ethanol sensitivity. The predicted amnesiac gene product, AMN, is an apparent preproneuropeptide, and previous studies suggest that it stimulates cAMP synthesis. Here we show that, unlike other learning-related Drosophila proteins, AMN is not preferentially expressed in mushroom bodies. Instead, it is strongly expressed in two large neurons that project over all the lobes of the mushroom bodies, a finding that sugge...

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Authors: Waddell, S; Armstrong, J; Kitamoto, T; Kaiser, K; Quinn, W

• Journal: Cell
• Volume: 103
• Issue: 5
• Pages: 805-813
• Publication date: 2000-11-01
• DOI: 10.1016/s0092-8674(00)00183-5
• EISSN: 1097-4172
• ISSN: 0092-8674
• Language: English
• Keywords: Models, Biological; Time Factors; Animals, Genetically Modified; Cyclic AMP; Immunohistochemistry; Animals; Neurons; Temperature; Smell; Gene Deletion; Chromosomes; Drosophila Proteins; Memory; Phenotype; Neuropeptides; Peptides; Mutation; Brain; Genotype; Drosophila; Genes, Reporter