Journal article icon

Journal article

Denaturation of dsDNA immobilised at a negatively charged gold electrode is not caused by electrostatic repulsion

Abstract:

Double-stranded DNA immobilised through a thiol anchor at a gold electrode surface can be unwound and denatured by applying a negative potential. One proposed mechanism for this electrochemical denaturation is that electrostatic field effects are responsible for the destabilisation of the dsDNA through repulsion of the DNA sugar-phosphate backbone away from the electrode surface. Herein, we demonstrate conclusively that electrochemical melting at gold electrodes cannot be explained solely as ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1039/c3sc22147d

Authors


Johnson, RP More by this author
Richardson, JA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Bartlett, PN More by this author
Journal:
CHEMICAL SCIENCE
Volume:
4
Issue:
4
Pages:
1625-1632
Publication date:
2013
DOI:
EISSN:
2041-6539
ISSN:
2041-6520
URN:
uuid:bea65291-0f2b-48c9-8b51-0726ed0c4a8c
Source identifiers:
400106
Local pid:
pubs:400106
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP