Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus?

Journal article

Depression is the most common neuropsychiatric co-morbidity in Parkinson's disease (PD). The underlying mechanism of depression in PD is complex and likely involves biological, psychosocial and therapeutic factors. The biological mechanism may involve changes in monoamine systems, in particular the serotonergic (5-hydroxytryptamine, 5-HT) system. It is well established that the 5-HT system is markedly affected in the Parkinsonian brain, with evidence including pathological loss of markers of ...

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Authors: Tan, S; Hartung, H; Sharp, T; Temel, Y

• Publication status: Published
• Journal: Neuropharmacology
• Volume: 61
• Issue: 3
• Pages: 387-399
• Publication date: 2011-09-01
• DOI: 10.1016/j.neuropharm.2011.01.006
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: Subthalamic Nucleus; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission; Deep Brain Stimulation; Basal Ganglia; Animals; Raphe Nuclei; Parkinson Disease; Nerve Tissue Proteins; Humans; Neurons; Depression; Serotonin