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Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus?

Abstract:

Depression is the most common neuropsychiatric co-morbidity in Parkinson's disease (PD). The underlying mechanism of depression in PD is complex and likely involves biological, psychosocial and therapeutic factors. The biological mechanism may involve changes in monoamine systems, in particular the serotonergic (5-hydroxytryptamine, 5-HT) system. It is well established that the 5-HT system is markedly affected in the Parkinsonian brain, with evidence including pathological loss of markers of ...

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Publication status:
Published

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Authors


Hartung, H More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Neuropharmacology
Volume:
61
Issue:
3
Pages:
387-399
Publication date:
2011-09-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:bea17364-167b-44c3-8844-a22a75972bce
Source identifiers:
185100
Local pid:
pubs:185100

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