- Abstract:
-
Depression is the most common neuropsychiatric co-morbidity in Parkinson's disease (PD). The underlying mechanism of depression in PD is complex and likely involves biological, psychosocial and therapeutic factors. The biological mechanism may involve changes in monoamine systems, in particular the serotonergic (5-hydroxytryptamine, 5-HT) system. It is well established that the 5-HT system is markedly affected in the Parkinsonian brain, with evidence including pathological loss of markers of ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.neuropharm.2011.01.006
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- Journal:
- Neuropharmacology
- Volume:
- 61
- Issue:
- 3
- Pages:
- 387-399
- Publication date:
- 2011-09-05
- DOI:
- EISSN:
-
1873-7064
- ISSN:
-
0028-3908
- URN:
-
uuid:bea17364-167b-44c3-8844-a22a75972bce
- Source identifiers:
-
185100
- Local pid:
- pubs:185100
- Copyright date:
- 2011
Journal article
Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus?
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