- Abstract:
-
The AU-rich element (ARE) is an important instability determinant for a large number of early-response-gene mRNAs. AREs also mediate the stabilization of certain pro-inflammatory mRNAs, such as tumour necrosis factor (TNF)-alpha and cyclo-oxygenase-2 (COX-2), in response to inflammatory stimuli. To understand how AREs control mRNA stability, it is necessary to identify trans-acting factors. We have purified a new ARE-binding protein and identified it as CArG box-binding factor-A (CBF-A). The ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1042/BJ20020402
-
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- Journal:
- The Biochemical journal
- Volume:
- 366
- Issue:
- Pt 3
- Pages:
- 709-719
- Publication date:
- 2002-09-05
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- URN:
-
uuid:be9e59d0-15b9-4ef6-b7a8-859b2a58190f
- Source identifiers:
-
224570
- Local pid:
- pubs:224570
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Identification of a novel AU-rich-element-binding protein which is related to AUF1.
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