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Identification of a novel AU-rich-element-binding protein which is related to AUF1.

Abstract:

The AU-rich element (ARE) is an important instability determinant for a large number of early-response-gene mRNAs. AREs also mediate the stabilization of certain pro-inflammatory mRNAs, such as tumour necrosis factor (TNF)-alpha and cyclo-oxygenase-2 (COX-2), in response to inflammatory stimuli. To understand how AREs control mRNA stability, it is necessary to identify trans-acting factors. We have purified a new ARE-binding protein and identified it as CArG box-binding factor-A (CBF-A). The ...

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Publication status:
Published

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Publisher copy:
10.1042/BJ20020402

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Rawlinson, L More by this author
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Journal:
The Biochemical journal
Volume:
366
Issue:
Pt 3
Pages:
709-719
Publication date:
2002-09-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:be9e59d0-15b9-4ef6-b7a8-859b2a58190f
Source identifiers:
224570
Local pid:
pubs:224570

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