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Quantifying the genetic risk for the development of axial spondyloarthropathy: could this become a diagnostic tool?

Abstract:

To assess the utility of recent genetic findings in ankylosing spondylitis (AS) and axial spondyloarthropathy (SpA) in relation to diagnostic testing, prognosis and responses to biologic treatment and the development of new therapies.AS and other forms of SpA are polygenic with more than 100 genes contributing to disease susceptibility. The role of genes in determining the outcome of the disease and response to treatment is less clear. Here, we review some of the progress that has been made o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1097/bor.0000000000000517

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
Green Templeton College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
ORCID:
0000-0002-8398-0010
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
New College
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Funding agency for:
Vecellio, M
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Grant:
20773
20796
18797
19536
Publisher:
Lippincott, Williams and Wilkins Publisher's website
Journal:
Current Opinion in Rheumatology Journal website
Volume:
30
Issue:
4
Pages:
319–323
Publication date:
2018-07-01
Acceptance date:
2018-04-03
DOI:
EISSN:
1531-6963
ISSN:
1040-8711
Pubs id:
pubs:846143
URN:
uri:be9ca365-59bf-4282-9e61-5a04d0138dc9
UUID:
uuid:be9ca365-59bf-4282-9e61-5a04d0138dc9
Local pid:
pubs:846143

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