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The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.

Abstract:

Tissue inhibitors of metalloproteinases (TIMPs) are widely distributed in the animal kingdom and the human genome contains four paralogous genes encoding TIMPs 1 to 4. TIMPs were originally characterized as inhibitors of matrix metalloproteinases (MMPs), but their range of activities has now been found to be broader as it includes the inhibition of several of the disintegrin-metalloproteinases, ADAMs and ADAMTSs. TIMPs are therefore key regulators of the metalloproteinases that degrade the ex...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Biochimica et biophysica acta
Volume:
1803
Issue:
1
Pages:
55-71
Publication date:
2010-01-05
DOI:
ISSN:
0006-3002
URN:
uuid:be8e91f4-807d-4966-b86d-83a12c12d00d
Source identifiers:
226540
Local pid:
pubs:226540

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