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Characterization of SNARE proteins in human pituitary adenomas: targeted secretion inhibitors as a new strategy for the treatment of acromegaly?

Abstract:

CONTEXT: Targeted secretion inhibitors (TSIs), a new class of recombinant biotherapeutic proteins engineered from botulinum toxin, represent a novel approach for treating diseases with excess secretion. They inhibit hormone secretion from targeted cell types through cleavage of SNARE (soluble N-ethylmaleimide-sensitive factor-activating protein receptor) proteins. qGHRH-LH(N)/D is a TSI targeting pituitary somatotroph through binding to the GHRH-receptor and cleavage of the vesicle-associated...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2013-2602

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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
98
Issue:
12
Pages:
E1918-E1926
Publication date:
2013-12-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:be7c2018-c778-4720-8af0-a4244e49c434
Source identifiers:
436116
Local pid:
pubs:436116

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