Journal article icon

Journal article

Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure.

Abstract:

OBJECTIVE: To verify whether a deficiency in the cardiac sarcoplasmic reticulum pump SERCA2a causes cardiac dysfunction in humans. DESIGN: Cardiac performance was measured in a serendipitous human model of primary SERCA2a deficiency, Darier's disease, an autosomal dominant skin disorder caused by mutations inactivating one copy of the ATP2A2 gene, which encodes SERCA2a. METHODS: Systolic and diastolic function and contractility were assessed by echocardiography at rest and during exercise in...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1136/hrt.2004.051037

Authors


Mayosi, BM More by this author
Davies, CH More by this author
Gumedze, F More by this author
Hovnanian, A More by this author
Expand authors...
Journal:
Heart (British Cardiac Society)
Volume:
92
Issue:
1
Pages:
105-109
Publication date:
2006-01-05
DOI:
EISSN:
1468-201X
ISSN:
1355-6037
URN:
uuid:be7613e7-193a-44a4-90c1-608c6b5a0f06
Source identifiers:
80054
Local pid:
pubs:80054

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP