Journal article icon

Journal article

Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival.

Abstract:

Degeneration of the neural retina is the leading cause of untreatable blindness in the developed world. Stem cell replacement therapy offers a novel strategy for retinal repair. Postmitotic photoreceptor precursors derived from the early postnatal (P) retina are able to migrate and integrate into the adult mouse retina following transplantation into the subretinal space, but it is likely that a large number of these cells would be required to restore vision. The adult recipient retina presen...

Expand abstract

Actions


Access Document


Publisher copy:
10.3727/096368911x623871

Authors


Pearson, RA More by this author
Gonzalez-Cordero, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Expand authors...
Journal:
Cell transplantation
Volume:
21
Issue:
5
Pages:
871-887
Publication date:
2012
DOI:
EISSN:
1555-3892
ISSN:
0963-6897
URN:
uuid:be74c228-e22b-490f-9381-0906cc0bf1eb
Source identifiers:
254291
Local pid:
pubs:254291

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP