Pancreatic islets have a central role in blood glucose homeostasis. In addition to insulin-producing beta-cells and glucagon-secreting alpha-cells, the islets contain somatostatin-releasing delta-cells. Somatostatin is a powerful inhibitor of insulin and glucagon secretion. It is normally secreted in response to glucose and there is evidence suggesting its release becomes perturbed in diabetes. Little is known about the control of somatostatin release. Closure of ATP-regulated K(+)-channels (...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.
If you are the owner of this record, you can report an update to it here: Report update to this record