R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

Journal article

Pancreatic islets have a central role in blood glucose homeostasis. In addition to insulin-producing beta-cells and glucagon-secreting alpha-cells, the islets contain somatostatin-releasing delta-cells. Somatostatin is a powerful inhibitor of insulin and glucagon secretion. It is normally secreted in response to glucose and there is evidence suggesting its release becomes perturbed in diabetes. Little is known about the control of somatostatin release. Closure of ATP-regulated K(+)-channels (...

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Authors: Zhang, Q; Bengtsson, M; Partridge, C; Salehi, A; Braun, M

• Publication status: Published
• Journal: Nature cell biology
• Volume: 9
• Issue: 4
• Pages: 453-460
• Publication date: 2007-04-01
• DOI: 10.1038/ncb1563
• EISSN: 1476-4679
• ISSN: 1465-7392
• Language: English
• Keywords: Dose-Response Relationship, Drug; Animals; Mannoheptulose; Calcium Channels, R-Type; Isradipine; Potassium Channel Blockers; Mice, Inbred C57BL; Immunohistochemistry; Glucose; Mice; Membrane Potentials; Oxazoles; Potassium Channels; Mice, Inbred Strains; Diazoxide; Macrocyclic Compounds; Mice, Knockout; Cytophotometry; Calcium; Microscopy, Confocal; Somatostatin; Potassium; Electrophysiology; Ryanodine; Somatostatin-Secreting Cells; Islets of Langerhans