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R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

Abstract:

Pancreatic islets have a central role in blood glucose homeostasis. In addition to insulin-producing beta-cells and glucagon-secreting alpha-cells, the islets contain somatostatin-releasing delta-cells. Somatostatin is a powerful inhibitor of insulin and glucagon secretion. It is normally secreted in response to glucose and there is evidence suggesting its release becomes perturbed in diabetes. Little is known about the control of somatostatin release. Closure of ATP-regulated K(+)-channels (...

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Publication status:
Published

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Publisher copy:
10.1038/ncb1563

Authors


Bengtsson, M More by this author
Partridge, C More by this author
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Journal:
Nature cell biology
Volume:
9
Issue:
4
Pages:
453-460
Publication date:
2007-04-05
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
URN:
uuid:be703149-4cf3-4c2d-a0af-1f4cd82c5915
Source identifiers:
14938
Local pid:
pubs:14938

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